Journal of Biochemicals and Phytomedicine 2958-8561 4 2 2025 12 15 Formulation and Design of Antidiabetic Tablets from Eucalyptus camaldulensis Using Wet Granulation and a 2³ Factorial Design 34 41 10.34172/jbp.2025.15 EN Azza Dawoud. H. Dawoud https://orcid.org/0009-0004-9847-8148 Daud Baraka Abdalla https://orcid.org/0000-0001-8866-0422 Journal Article 10.34172/jbp.2025.15 2025 04 30 2025 07 10 Introduction: Eucalyptus camaldulensis, recognized for its antidiabetic and antimicrobial properties, was formulated into an oral tablet to improve its clinical applicability. This study optimized critical formulation parameters via a 2³ factorial design to produce tablets meeting pharmacopeial standards. Methods: Eight formulations were prepared by wet granulation, evaluating three independent variables: binder (PVP) concentration, disintegrant (croscarmellose sodium) concentration, and kneading time. Tablets were assessed for weight variation, thickness, hardness, friability, disintegration time, and drug release in 0.1N HCl (paddle method, 75 rpm) analyzed at 258 nm. Results: All formulations complied with standard requirements. Tablet hardness ranged from 4.42–5.42 kg, friability was <1%, and disintegration time varied between 0.55–2 minutes. Drug release at 45 minutes exceeded 91.4%, with some formulations reaching 98.8%. Factorial analysis identified optimal variable levels for quality attributes. Conclusion: E. camaldulensis was successfully formulated into rapidly disintegrating tablets with high drug release, suitable for potential use in type 2 diabetes management. Further in vivo and clinical studies are warranted.