Journal of Biochemicals and Phytomedicine 2958-8561 4 2 2025 12 15 Phytomedicine 4.0: Incorporating Omics Technology, Nanotechnology and Sustainable Chemistry to create next-generation plant-derived therapeutics 1 3 10.34172/jbp.2025.11 EN Alireza Heidari https://orcid.org/0000-0003-2655-133X Abdelkader Zarrouk https://orcid.org/0000-0002-5495-2125 EDITORIAL 10.34172/jbp.2025.11 2025 06 16 2025 07 19 The discipline of phytomedicine is entering a transformative period—what we might term "Phytomedicine 4.0"—where high throughput omics technologies, nano-enabled delivery systems, and frameworks for green and sustainable chemistry converge together to change the ways in which plant-derived therapeutics are discovered, developed and translated into practice. In this commentary, we outline the current state of the art, highlight major translational and regulatory challenges and propose a research agenda that will further advance the discipline through the mid-2020s and beyond.